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What are some strategies to reduce lead time bias in studies evaluating the efficacy of screening programs?

Epiville: Screening • Think of hypothetical screening programs for diseases of interest to you; find one example of a disease where high sensitivity would be more important, and one example where high specificity would be more important. • You have probably had the experience of being screened many times (e.g., cholesterol test, glucose level test, blood pressure measurement). What is more important information from a PATIENT’s point of view (PPV/NPV vs. Sensitivity/Specificity), and what is more important information from a PHYSICIAN’s point of view (PPV/NPV vs. Sensitivity/Specificity). • What are some strategies to reduce lead time bias in studies evaluating the efficacy of screening programs?

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