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Calculate the percent attributable risk of Coronary Heart Disease due to smoking

Calculate the percent attributable risk of Coronary Heart Disease due to smoking

COH 315: Principles of Epidemiology Final Part 1 Calculations and Interpretations: Answer the following questions in the space provided. [http://www.bezern.com/] Show all of your work. [http://www.bezern.com/] 1. [http://www.bezern.com/] Evidence of an increased risk of lung cancer associated with cigarette smoking was sought by Doll and Hill. [http://www.bezern.com/] In one study, 649 lung cancer cases were matched by age, and gender to 649 controls; 647 of the cases and 622 of the control had a history of smoking cigarettes. [http://www.bezern.com/] a. [http://www.bezern.com/] Name the type of study. [http://www.bezern.com/] b. [http://www.bezern.com/] Create the appropriate 2X2 table for the study. [http://www.bezern.com/] (2 points) Lung Cancer Controls Smokers 647 622 Nonsmokers 2 27 Total 649 649 c. [http://www.bezern.com/] Calculate the appropriate measure of association for the study. [http://www.bezern.com/] (4 points) d. [http://www.bezern.com/] Interpret the results. [http://www.bezern.com/] (2 points) 2. [http://www.bezern.com/] In another study, the smoking habits of 34,445 male physicians were obtained by mailed questionnaires. [http://www.bezern.com/] Deaths among these physicians over the subsequent years were identified though contact with the office of the Registrar General. [http://www.bezern.com/] The death rates from lung cancer of these physicians classified by smoking habits were : Standardized Death Rates per 1000 Persons Aged 35 or More per Year Nonsmokers 0. [http://www.bezern.com/]07 Cigarette Smokers 0. [http://www.bezern.com/]96 a. [http://www.bezern.com/] Name the type of study. [http://www.bezern.com/] (2 points) b. [http://www.bezern.com/] Calculate the Relative Risk for smokers as compared to nonsmokers. [http://www.bezern.com/] (6 points) c. [http://www.bezern.com/] Interpret the results (2 points) Annual Death Rates per 100,000 Persons Exposure Category Lung Cancer Coronary Heart Disease Heavy Smokers 166 599 Nonsmokers 7 422 a. [http://www.bezern.com/] Calculate the relative risk from Lung Cancer Mortality for Heavy Smokers compared to non smokers. [http://www.bezern.com/] ( 4 points) b. [http://www.bezern.com/] Calculate the attributable risk of Lung Cancer from smoking. [http://www.bezern.com/] (4 points) c. [http://www.bezern.com/] Interpret the results. [http://www.bezern.com/] (2 points) d. [http://www.bezern.com/] Calculate the percent attributable risk of Coronary Heart Disease due to smoking (4 points) e. [http://www.bezern.com/] Interpret the results. [http://www.bezern.com/] (2 points) 3. [http://www.bezern.com/] Convert the following incidence rates to attributable risk using the additive model: (5 points) Incidence Rates Relative Risks Factor A Factor A _ + _ + Factor B – 3. [http://www.bezern.com/]0 9. [http://www.bezern.com/]0 _____________________________________ __________________________________ + 15. [http://www.bezern.com/]0 21. [http://www.bezern.com/]00 4. [http://www.bezern.com/] Calculate the concordance rate for the following data: (5 points) Twin 1 Has Leukemia Does Not Have Leukemia Twin 2 Has Leukemia 14 1 Does Not Have Leukemia 26 36

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